Genomics

Dataset Information

0

Comparative genomic hybridization of 20 patients with Sézary syndrome


ABSTRACT: The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent E2A gene deletion in at least 70% of patients with Sézary syndrome (SS), a subtype of T cell lymphoma. Loss of E2A results in enhanced proliferation and cell cycle progression via derepression of the proto-oncogene MYC and the cell cycle regulator CDK6. Furthermore, by examining the gene expression profile of SS cells following restoration of E2A expression, we identify a number of E2A-regulated genes that interfere with oncogenic signaling pathways including the Ras pathway. Several of these genes are down-regulated or lost in primary SS tumor cells. These data demonstrate a tumor suppressor function of E2A in human lymphoid cells and could help to develop new treatment strategies for human lymphomas with altered E2A activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19000 | GEO | 2011/07/07

SECONDARY ACCESSION(S): PRJNA129051

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-21730 | biostudies-arrayexpress
2011-07-07 | GSE21730 | GEO
2022-12-31 | GSE192836 | GEO
2022-03-04 | GSE146586 | GEO
2015-07-01 | GSE59179 | GEO
| E-GEOD-59179 | biostudies-arrayexpress
2009-09-30 | GSE17595 | GEO
2009-09-30 | GSE17601 | GEO
| E-GEOD-17602 | biostudies-arrayexpress
2016-12-12 | GSE64119 | GEO