Transcriptomics

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VDR-dependent signaling modulates neuroinflammation in the acute phase of ischemic stroke


ABSTRACT: VDR deficiency in microglia markedly aggravated infarct volumes, neurological deficits, and neuroinflammation after cerebral ischemia. To investigate the role of VDR in microglia-regulated neuroinflammation, we performed RNA-seq analysis on microglia isolated from poststroke microglia-conditional VDR knockout (Vdr-cKO) mice and littermate controls. VDR elimination dramatically alters the gene expression profiles of postischemic microglia, implying that vitamin D signaling play a crucial role in microglia-modulated stroke pathogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE190171 | GEO | 2023/06/21

REPOSITORIES: GEO

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