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Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with dihydromyricetin

ABSTRACT: Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of dihydromyricetin (DMY), a bioactive phytochemical constituent that can be found in natural plants such as Rattan tea extract (RTE), in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of DMY as medicinal agent in controlling the influence of senescent human stromal cells and provides a strong rationale for its future use in aging intervention and geriatric medicine.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190280 | GEO | 2025/12/31

REPOSITORIES: GEO

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