EYA4 is a non-small cell lung cancer tumor suppressor located in the susceptibility locus on chromosome 6q

ABSTRACT: This study was undertaken to identify novel tumour suppressor genes in lung adenocarcinoma. EYA4, located at 6q23.2 was identified as a frequently lost and hypermethylated gene in the analyzed samples. EYA4 is underexpressed in addition to being deleted and hypermethylated. Control of EYA4 expression by DNA methylation was assessed using 5'-azacytidine. The role of EYA4 in apoptosis was assessed using a stable knock down of the gene which was assessed for apoptotis using FACS and qPCR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19034 | GEO | 2014/02/25

SECONDARY ACCESSION(S): PRJNA120637

REPOSITORIES: GEO