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Vitamin C deficiency causes cell type-specific epigenetic reprogramming and acute tubular necrosis

ABSTRACT: The recently described roles of vitamin C as an epigenetic regulator playsa crucial role in normal physiological development and pathological conditions.However, the epigenetic regulatory role of vitamin C in renal homeostasis andpathogenesis remains largely unknown. We aim to reveal that vitamin C deficiency promoted acute tubular necrosis,and provide a potential mechanism for epigenetic therapy in preventing the progression of chronic kidney disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE190371 | GEO | 2021/12/09

REPOSITORIES: GEO

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