Human FcgRIIa mediates attenuation of IFN-I response in human monocytes

ABSTRACT: It is generally believed that there is continued cross-regulation between adaptive humoral immunity and Type I interferon (IFN-I) response during viral infections, but the question how antibodies (Abs), and/or Ab-antigen immunocomplexes (ICs), regulate IFN-I production and/or signaling in immune cells remains unanswered. Here we report that plate-coated IgG (cIgG), a mimic IC without antigen restriction, could dampen IFN-I signaling in monocytes through FcgRIIa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190623 | GEO | 2024/12/10

REPOSITORIES: GEO