Longitudinal single-cell RNA-sequencing (scRNAseq) of broncho-alaveolar compartment of rhesus macaque model of COVID-19
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ABSTRACT: To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection in airways, we performed longitudinal scRNA-Seq of the broncho-alveolar lavage (BAL) cells isolated from SARS-CoV-2 infected rhesus macaques. We found early induction of innate type-1 interferon responses with accumulation of a distinct macrophage population that possesses an interferon-driven innate anti-viral gene signature early during infection.
ORGANISM(S): Macaca mulatta
PROVIDER: GSE190659 | GEO | 2021/12/13
REPOSITORIES: GEO
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