Transcriptomics,Genomics

Dataset Information

0

RNA-seq for AML samples


ABSTRACT: Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to explore RNA-seq results for AML samples. Overall design: 9 AML samples

INSTRUMENT(S): Illumina NovaSeq 6000 (Homo sapiens)

ORGANISM(S): Homo Sapiens

SUBMITTER: Fang Fang  

PROVIDER: GSE190775 | GEO | 2022-07-20

REPOSITORIES: GEO

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Publications

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia.

Fang Fang F   Lu Jun J   Sang Xu X   Tao Yan-Fang YF   Wang Jian-Wei JW   Zhang Zi-Mu ZM   Zhang Yong-Ping YP   Li Xiao-Lu XL   Xie Yi Y   Wu Shui-Yan SY   Chu Xin-Ran XR   Li Gen G   Wu Di D   Chen Yan-Ling YL   Yu Juan-Juan JJ   Jia Si-Qi SQ   Feng Chen-Xi CX   Tian Yuan-Yuan YY   Li Zhi-Heng ZH   Ling Jing J   Hu Shao-Yan SY   Pan Jian J  

Journal of experimental & clinical cancer research : CR 20220716 1


<h4>Background</h4>Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In this study, we explored super-enhancer profiling through ChIP-Seq analysis of AML samples and AML cell lines, followed by functional analysis.<h4>Methods</h4>ChIP-seq analysis for H3K27ac was performed in 11 AML samples, 7 T-ALL samples, 8 B-ALL samples, and in NB4 cell  ...[more]

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