Single nucleus RNA-seq of prefrontal cortex from methamphetamine-treated mice and control mice

ABSTRACT: As one of the most commonly abused substances in the world, methamphetamine (METH) addiction and use disorders cause a huge burden for society. The prefrontal cortex (PFC) is a vital brain region associated with emotion and cognitive behaviors that is also intimately involved in the neurocircuitry of addiction syndrome. Bulk RNA-seq has revealed the effects of METH on disease-related genes alterations in the mouse PFC; however, the roles of different cell types are still unknown. We performed single nucleus RNA sequencing (snRNA-seq) to examine the transcriptomes of 20,698 nuclei isolated from the PFC of chronic METH-treated and control mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE190800 | GEO | 2021/12/15

REPOSITORIES: GEO