Transcriptomics,Genomics

Dataset Information

33

Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T cell recovery.


ABSTRACT: Analysis of peripheral blood mononuclear cells (PBMCs) taken from 24 HIV-infected male participants before the start of highly active antiretroviral therapy (HAART). Results identify biomarkers for the identification of HIV-infected participants that progress to good versus poor CD4+ T cell recovery after 48 weeks of HAART. Overall design: This retrospective study evaluated PBMC gene expression in cells taken within 2 weeks before intitiation of HAART from 24 recently HIV-infected individuals to identify genes whose expression is predictive of CD4+ T cell recovery after 48 weeks of HAART.

REANALYSED by: E-GEOD-44228

INSTRUMENT(S): Illumina HumanWG-6 v3.0 expression beadchip

SUBMITTER: Christopher Woelk  

PROVIDER: GSE19087 | GEO | 2009-12-03

SECONDARY ACCESSION(S): PRJNA120503

REPOSITORIES: GEO

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Publications

Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery.

Woelk Christopher H CH   Beliakova-Bethell Nadejda N   Goicoechea Miguel M   Zhao Yingdong Y   Du Pinyi P   Rought Steffney E SE   Lozach Jean J   Pérez-Santiago Josué J   Richman Douglas D DD   Smith Davey M DM   Little Susan J SJ  

AIDS (London, England) 20100101 2


To identify a pre-HAART gene expression signature in peripheral blood mononuclear cells (PBMCs) predictive of CD4 T-cell recovery during HAART in HIV-infected individuals.This retrospective study evaluated PBMC gene expression in 24 recently HIV-infected individuals before the initiation of HAART to identify genes whose expression is predictive of CD4 T-cell recovery after 48 weeks of HAART.The change in CD4 T-cell count (DeltaCD4) over the 48-week study period was calculated for each of the 24  ...[more]

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