Hepatocyte RNA-seq analysis in liver-specific XBP1 knockout mice fed a high fat sugar diet

ABSTRACT: X-box binding protein 1 (XBP1) is a key component of the unfolded protein response (UPR) and plays important roles in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD). Mice with liver-specific XBP1 deletion developed great liver injury and fibrosis in a dietary model of NAFLD. This project is to investigate hepatocyte-specific transcriptome profiling in XBP1-deficient mice fed a high fat sugar diet.

ORGANISM(S): Mus musculus

PROVIDER: GSE190947 | GEO | 2022/01/03

REPOSITORIES: GEO