Engineered tRNAs suppress nonsense mutations in cells and in vivo

ABSTRACT: we introduce a strategy to repurpose sense-codon decoding tRNA into efficient suppressors of the three nonsense mutation-induced PTCs (UGA, UAG and UAA). The suppressor tRNAs restore function of a model and disease-related protein

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE191048 | GEO | 2023/04/04

REPOSITORIES: GEO