CXCR3-expressing macrophages regulate angiogenesis, tumor cell proliferation and immune evasion in hepatocellular carcinoma

ABSTRACT: Chemokine receptor CXCR3 shapes the intrahepatic tumor microenvironment in a highly dynamic manner. Genetic deletion of Cxcr3 has an impact on the development and differentiation of myeloid cells and improves potentially oncogenic properties of tumor-associated macrophages in hepatocellular carcinoma (HCC) bearing mice. This ultimately leads to an increased carcinogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE191156 | GEO | 2024/12/01

REPOSITORIES: GEO