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Parallels between oncogene-induced cardiac neoplasia and heart regeneration in zebrafish

ABSTRACT: We used a cardiac-specific tamoxifen-dependent Gal4-ERT2/UAS model to achieve uniform but conditionally regulated expression of the oncogene HRASG12V in zebrafish cardiomyocytes. We found that the inhibition of TOR signaling using rapamycin treatment counteracts neoplasic growth. We analyse the transcriptome of neoplasic ventricles after exposure to DMSO and rapamycin and we applied bioinformatic analysis to determine common and distinctive molecular signatures of neoplasia versus regeneration of the heart.

ORGANISM(S): Danio rerio

PROVIDER: GSE191324 | GEO | 2022/09/05

REPOSITORIES: GEO

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