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Analysis of copy number profiles of several tumor samples of same patient reveals the successive steps in tumorigenesis

ABSTRACT: We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis. This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19195 | GEO | 2009/12/01

SECONDARY ACCESSION(S): PRJNA120679

REPOSITORIES: GEO

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Analysis of copy number profiles of several tumor samples of same patient reveals the successive steps in tumorigenesis

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Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis.

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Project description:We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis. An algorithm was developed to reconstruct tumors lineage and the sequence of copy number alterations along tumorigenesis from the analysis of several samples from a same patient. The data here consist in Illumina SNP data from 20 bladder tumors. 15 of these tumors (REF1 to REF15) come from independent samples and were used to compute the frequencies of breakpoints at each location. The 5 other samples (S4_A, S4_B, S5_A, S5_B, and S5_C) are multiple tumors from 2 patients. They were used to reconstruct the sequence of chromosome aberrations along cancer development in these 2 patients.

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2010-05-19 | E-GEOD-19193 | biostudies-arrayexpress

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Array CGH in TAR syndrome

Project description:The series represents the analysis data of four TAR syndrome patients by submegabase resolution BAC array. Keywords: array CGH

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Genomic markers for malignant progression in pulmonary adenocarcinoma.

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