Expanding the genetic tool kit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum

ABSTRACT: We elucidated the global regulatory network of sigma E in Fusobacterium nucleatum. For this, we developed new genetic tools for the anaerobic bacterium. This uncovered a conserved regulon of the sigma factor including a noncoding arm of the sRNA FoxI. In this process, FoxI serves as a negative regulator of sigma E to downregulate several outer membrane proteins as well as the putative galactose transporter mglBAC.

ORGANISM(S): Fusobacterium nucleatum subsp. nucleatum ATCC 23726

PROVIDER: GSE192339 | GEO | 2022/09/20

REPOSITORIES: GEO