HLA-B*46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype

ABSTRACT: In an unbiased transcriptomic screen we observed reduced NK cell activation phenotypes in HLA-B*46 positive people with HIV. These findings show that contemporaneous treated cohorts can be used to analyze host genetic effects in HIV disease, and support a role for NK cells in HIV control revealed by unique properties of the recombinant HLA-B*46 allele which is frequent only in Asia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192384 | GEO | 2022/06/28

REPOSITORIES: GEO