Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice

ABSTRACT: The destruction of bone and cartilage results in a loss of joint functionality, critically impairing the quality of life in arthritis patients. Synovial fibroblasts (SFs) critically contribute to the pathogenesis of rheumatoid arthritis (RA) by acquiring either a pro-inflammatory or tissue-destructive phenotype. To explore the molecular mechanisms underlying the pathogenic fibroblast phenotype in arthritis, we performed single-cell RNA sequencing (scRNA-seq) on the synovial cells which were isolated from collagen-induced arthritis (CIA) mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE192504 | GEO | 2022/07/06

REPOSITORIES: GEO