Small Noncoding RNAome Changes during Human Bone Marrow Mesenchymal Stem Cells Senescence

ABSTRACT: The proliferation capability and functionality of BMSCs are known to decline with aging, which severely impairing the extensive applications of BMSCs-based therapies. In this study, replicative senescence model of hBMSCs was established and the expression changes of small noncoding RNAs during senescence was detected by small RNA high-throughput sequencing analysis and qPCR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192578 | GEO | 2021/12/27

REPOSITORIES: GEO