Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity V

ABSTRACT: Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection into C57BL/6J mice. tumor tissue has been isolated (~ 100 mm3) and total RNA were extracted by Trizol, followed by cDNA were sequenced by Illumina NextSeq 550.

ORGANISM(S): Mus musculus

PROVIDER: GSE193054 | GEO | 2023/07/09

REPOSITORIES: GEO