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Combination treatmetn of MRT68921 and all-trans retinoic acid in HL-60 human leukemia cells

ABSTRACT: It was previously reported that inhibition of autophagosome formation by MRT68921 induced accumulation of cytosolic dsDNA, which can activate cytosolic DNA-sensor signaling pathway, thereby reducing cell viability through reactive oxygen species generation in leukemia cells. Thus, we examined the effect of combination treatment of MRT68921 and a leukemia differentiation therapeutic drug, all-trans retinoic acid.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193056 | GEO | 2024/03/05

REPOSITORIES: GEO

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