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Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-1

ABSTRACT: Dkk4 transgenic mice in wild-type background showed abnormal hair subtype formation. Gene expression profiling showed significant down regulation of hair follicle-related keratin genes and hair keratin-associated protein genes at E18.5 and P1. Keywords: development or differentiation design,genetic modification design

ORGANISM(S): Mus musculus

PROVIDER: GSE19309 | GEO | 2010/09/03

SECONDARY ACCESSION(S): PRJNA123685

REPOSITORIES: GEO

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Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-1

Project description:Dkk4 transgenic mice in wild-type background showed abnormal hair subtype formation. Gene expression profiling showed significant down regulation of hair follicle-related keratin genes and hair keratin-associated protein genes at E18.5 and P1. Keywords: development or differentiation design,genetic modification design To define target genes of Dkk4 during hair follicle development, we carried out microarray experiments with mouse back skin samples that from 4 developmental time points including E14.5, E16.5, E18.5 and P1 of wild-type and wild-type background Dkk4 transgenic mice.

2010-09-03 | E-GEOD-19309 | biostudies-arrayexpress

Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2

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Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2

Project description:Dkk4 transgenic mice in Tabby background lack hair follicle formation. Gene expression profiling showed significant down regulation of Shh pathway genes at E16.5 and E17.5, the secondary hair follicle induction stages. Keywords: development or differentiation design,genetic modification design To define target genes of Dkk4 during secondary hair follicle induction, we carried out microarray experiments with mouse back skin samples that from 2 developmental time points including E16.5 and E17.5 of Tabby and Tabby background Dkk4 transgenic mice.

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Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair

Project description:This SuperSeries is composed of the following subset Series: GSE19309: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-1 GSE19312: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2 Refer to individual Series

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Project description: Not available

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Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

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Project description:This SuperSeries is composed of the SubSeries listed below.

2010-09-03 | GSE19364 | GEO