Single Cell RNA sequencing of BRONJ disease control and HMDP-treated mouse gingiva

ABSTRACT: Purpose: The goal of this study was to characterize the gingival oral barrier immunity of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and HMDP-treated BRONJ mouse maxilla. Method: Mouse BRONJ was induced by Zoledronate IV injection and maxillary left first molar extraction. HMDP-DNV was topically applied to the BRONJ lesion 2 times. Mouse palatal gingiva was harvested 2 weeks after tooth extraction. Gingival cells were harvested and subjected to 10X Genomix scRNA-seq. Cell Ranger processed data were analysed.

ORGANISM(S): Mus musculus

PROVIDER: GSE193110 | GEO | 2022/01/08

REPOSITORIES: GEO