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Single cell RNA sequencing reveals deep homology of dental cell types across vertebrates

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Maylandia zebra

PROVIDER: GSE193287 | GEO | 2022/02/08

REPOSITORIES: GEO

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Single cell RNA sequencing reveals deep homology of dental cell types across vertebrates [TJ]

Project description:Here we use single nuclei RNA sequencing (snRNA-seq) of replacement teeth and adjacent oral lamina in Lake Malawi cichlids, species with lifelong whole-tooth replacement, to make two main discoveries. First, despite hundreds of millions of years of evolution, we demonstrate conservation of cell type gene expression across vertebrate teeth (fish, mouse, human). Second, we used an approach that combines marker gene expression and developmental potential of dental cells to uncover the transcriptional signature of stem-like cells in regenerating teeth. Our work underscores the importance of a comparative framework in the study of vertebrate oral and regenerative biology.

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