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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ATAC-Seq]

ABSTRACT: We report ATAC seq of white preadipocytes from iWAT of WT and HMGN1 and HMGN2 double knockout (DKO) mice .

ORGANISM(S): Mus musculus

PROVIDER: GSE193332 | GEO | 2022/10/19

REPOSITORIES: GEO

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ChIP-Seq]

Project description:We report H3K27ac ChIP seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice .

2022-10-19 | GSE193333 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [RNA-Seq]

Project description:We report mRNA seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice . Moreover, we support our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

2022-10-19 | GSE193338 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [scRNA-Seq]

Project description:We report single-cell RNA seq (scRNA seq) at day 0 and day 6 of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice. This supports our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE193463 | GEO

Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins

Project description:To investigate the molecular mechanism of nucleosomal binding proteins HMGN regulating ameloblast differentiation We performed RNA-seq analysis of dental epithelium cells that were dissected from WT and DKO (Hmgn1-/-; Hmgn2-/-) mouse molars at three developmental stages.

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Brown and white adipocyte differentiation

Project description:Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and increased energy expenditure potential, is a legitimate strategy for combating obesity. The unique transcriptional regulators of the primary brown adipocyte phenotype are unknown, limiting our ability to promote brown adipogenesis over white. In the present work, we used microarray analysis strategies to study primary preadipocytes, and we made the striking discovery that brown preadipocytes demonstrate a myogenic transcriptional signature, whereas both brown and white primary preadipocytes demonstrate signatures distinct from those found in immortalized adipogenic models. We found a plausible SIRT1-related transcriptional signature during brown adipocyte differentiation that may contribute to silencing the myogenic signature. In contrast to brown preadipocytes or skeletal muscle cells, white preadipocytes express Tcf21, a transcription factor that has been shown to suppress myogenesis and nuclear receptor activity. In addition, we identified a number of developmental genes that are differentially expressed between brown and white preadipocytes and that have recently been implicated in human obesity. The interlinkage between the myocyte and the brown preadipocyte confirms the distinct origin for brown versus white adipose tissue and also represents a plausible explanation as to why brown adipocytes ultimately specialize in lipid catabolism rather than storage, much like oxidative skeletal muscle tissue. Keywords: In vitro differentiation

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Methylation profiling of cold exposure induced browning of white fat

Project description:We set two groups of 2-month-old C57BL6/J male mice at either thermoneutral temperature of 30℃ or under cold stimulation at 4℃ for one week. To identify events vital to beige fat activation, we performed MeRIP-seq using mice subcutaneous adipose tissue (iWAT) and focused on differentially-expressed genes characterized significant upregulation.

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Tanscriptome profiling of cold exposure induced browning of white fat

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2023-08-20 | GSE222424 | GEO

Transcription profiling of mouse brown and white adipocyte differentiated and undifferentiated states

2009-04-08 | E-GEOD-7032 | biostudies-arrayexpress

Whole genome bisulfite sequencing (WGBS) and RNA-sequencing of preadipocytes from iWAT

Project description:C57BL/6J male mice received a high-fat diet. DNA methylation profiles by WGBS of preadipocytes from iWAT of Tet3 f/f and Pdgfra-Tet3 KO mice. Expression profiling by RNA-sequencing of preadipocytes from iWAT of Tet3 f/f and Pdgfra-Tet3 KO mice.

2023-10-03 | GSE214483 | GEO

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