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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ChIP-Seq]

ABSTRACT: We report H3K27ac ChIP seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice .

ORGANISM(S): Mus musculus

PROVIDER: GSE193333 | GEO | 2022/10/19

REPOSITORIES: GEO

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HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [RNA-Seq]

Project description:We report mRNA seq during time course of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice . Moreover, we support our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

2022-10-19 | GSE193338 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [scRNA-Seq]

Project description:We report single-cell RNA seq (scRNA seq) at day 0 and day 6 of white preadipocyte browning from WT and HMGN1 and HMGN2 double knockout (DKO) mice. This supports our finding that loss of HMGN promotes white adipocyte browning with RNA seq of WT and DKO MEFs transdifferentiation into brown-like adipocytes.

2022-10-19 | GSE193462 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity [ATAC-Seq]

Project description:We report ATAC seq of white preadipocytes from iWAT of WT and HMGN1 and HMGN2 double knockout (DKO) mice .

2022-10-19 | GSE193332 | GEO

HMGNs Regulate White Adipocyte Browning By Stabilizing Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE193463 | GEO

Expression data from browning inguinal white adipose tissue in UCP1/ApoE-DKO mice

Project description:Differentiation of brown adipocytes is a crucial process for adaptive thermogenesis, which is stimulated by various factors. We found robust browning of inguinal white adipose tissue in UCP1/ApoE-DKO mice, but not in ApoE-KO mice, under high-fat diet condition. We used microarray to determine the genes specifically regulated in the browning white adipose tissue in UCP1/ApoE-DKO mice.

2018-10-01 | GSE95273 | GEO

Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins

Project description:To investigate the molecular mechanism of nucleosomal binding proteins HMGN regulating ameloblast differentiation We performed RNA-seq analysis of dental epithelium cells that were dissected from WT and DKO (Hmgn1-/-; Hmgn2-/-) mouse molars at three developmental stages.

2024-02-14 | GSE226942 | GEO

snRNA-seq of Lepr-cre; Tomato inWAT at different white-browning treatments

Project description:As obesity has becoming an urged issue nowadays, delineation of the mechanisms of WAT tissue white-browning and beige adipose origin are of important topic. By the use of snRNA-seq, we can outline LepR cells play important role in the white-browning process and investigate the mechanisms participate at different white-browning treatments.

2022-11-06 | GSE216925 | GEO

Cold-treated and Fasting-treated white-browning effect in inWAT

Project description:To investigate the white-browning effect in inguinal WAT tissue by cold-treated and fasting-treated

2022-11-09 | GSE217290 | GEO

SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ

Project description:The adipose tissue is a key site regulating energy metabolism. One of the contributing factors behind this is browning of white adipose tissue (WAT), however, knowledge of the intracellular determinants of browning process remains incomplete. By generating adipocyte-specific Senp2 knockout (Senp2-aKO) mice, here we showed that SENP2 negatively regulates browning by de-conjugating SUMO from C/EBPβ. Senp2-aKO mice were resistant to diet-induced obesity and insulin resistance due to increased energy expenditure and heat production. Senp2 knockout promoted beige adipocyte accumulation in inguinal WAT by upregulation of thermogenic gene expression. In addition, SENP2 knockdown promoted thermogenic adipocyte differentiation of precursor cells isolated from inguinal and epididymal WATs. Mechanistically, sumoylated C/EBPβ, a target of SENP2, suppressed expression of HOXC10, a browning inhibitor, by recruiting a transcriptional repressor DAXX. These findings indicate that a SENP2-C/EBPβ-HOXC10 axis operates for the control of beige adipogenesis in inguinal WAT.

2023-11-27 | GSE189387 | GEO

SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ

2023-11-27 | GSE189326 | GEO

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