Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential Metabolic Requirement Governed by Transcription Factor c-Maf Dictates Innate γδT17 Effector Functionality in Mice and Humans

ABSTRACT: To investigate the human γδT17 cells from oral cancers, we performed sc-RNAseq of two pairs of oral cancers with normal tissues.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193766 | GEO | 2022/04/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans.

Project description: Not available

| S-EPMC9132442 | biostudies-literature

Differential Metabolic Requirement Governed by Transcription Factor c-Maf Dictates Innate γδT17 Effector Functionality in Mice and Humans

Project description:Differential Metabolic Requirement Governed by Transcription Factor c-Maf Dictates Innate γδT17 Effector Functionality in Mice and Humans

| PRJNA797668 | ENA

Oral γδT17 cells induced by macrophages-derived extracellular vesicles in peridontitis exacerbate rheumatoid arthritis

Project description:Periodontitis (PD) is one of the most common human inflammatory diseases, yet the immunological mechanism linking oral and systemic immune responses are not well defined. Here, we show that the accumulation of interleukin-17 (IL-17)-producing γδT (γδT17) cells occurs not only in the oral cavity, but also in the peripheral lymph nodes and spleens in experimental periodontitis in mice. Strikingly, oral γδT17 cells derived from experimental periodontitis migrated to the inflamed joint and led to an exacerbation of rheumatoid arthritis (RA) in a collagen-induced arthritis model in mice. Mechansitically, we demonstrated that the dysbiosis in periodontitis led to an increase in production of complement component 3 (C3)-enriched extracellular vesicles (EVs) derived from macrophages. These C3-enriched EVs were taken up by γδT cells and stimulated intracellular C3a receptor to drive IL-17A production in γδT cells. Our findings revealed an previously unrecognized immunological mechanism linking periodontitis to RA through the accumulation and migration of oral γδT17 cells.

2026-04-08 | PXD063380 | Pride

NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for tumor growth

Project description:Calcium homeostasis is critical for cell proliferation, and emerging evidence shows that cancer cells exhibit altered calcium signals to fulfill their need for proliferation. However, it remains unclear whether there are oncogene-specific calcium homeostasis regulations that can expose novel therapeutic targets. Here, from RNAi screen, we report that adenosylhomocysteinase like protein 1 (AHCYL1), a suppressor of the endoplasmic reticulum (ER) calcium channel protein inositol trisphosphate receptor (IP3R), is selectively upregulated and critical for cell proliferation and tumor growth potential of human NRAS-mutated melanoma, but not for melanoma expressing BRAF V600E. Mechanistically, AHCYL1 deficiency results in decreased ER calcium levels, activates the unfolded protein response (UPR), and triggers downstream apoptosis. In addition, we show that AHCYL1 transcription is regulated by activating transcription factor 2 (ATF2) in NRAS-mutated melanoma. Our work provides evidence for oncogene-specific calcium regulations and suggests AHCYL1 as a novel therapeutic target for RAS mutant-expressing human cancers, including melanoma.

2024-01-15 | GSE253246 | GEO

NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth.

Project description: Not available

| S-EPMC10987265 | biostudies-literature

IL-17-producing γδT cells ameliorate intestinal acute graft-versus-host disease by recruitment of Gr-1+CD11b+ myeloid-derived suppressor cells

Project description:We generated γδT17 cells from splenocytes and compared gene expression profiles of initial and induced γδT17 cells using RNA-seq to explore their biological functions.

2021-01-06 | GSE164262 | GEO

Effect of fatty acid synthesis inhibition in IL-17-producing gamma delta T (γδT17) cells upon psoriatic inflammation

Project description:γδ T cells represent the primary innate source of IL-17 (γδT17) and are known to play a critical role in autoimmune and inflammatory diseases such as psoriasis. We here reported that psoriatic condition (IL-1b and IL-23) reshaped γδT17 cell metabolic signatures and promoted cytokine expression levels compared to homeostatic condition (IL-7). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs the fate of IL-17-producing CD4 T cells (Th17) differentiation. However, little is known about the role of ACC1-mediated FAS in their innate IL-17-producer counterpart, γδT17 cells. We further investigated the role of FAS in γδT17 by comparing the effect of pharmacological inhibitor Soraphen A (SorA) on DMSO vehicle under psoriatic conditions (IL-1b and IL-23). Interestingly, ACC inhibition shifts the lipid metabolism in γδT17 cells, which allows them to cope with lipid demand without affecting cellular viability.

2025-02-20 | GSE256512 | GEO

The RNA polymerase dictates ORF1 requirement and timing of LINE and SINE retrotransposition.

Project description: Not available

| S-EPMC2666806 | biostudies-literature

Natural γδT17 cell development and functional acquisition is governed by the mTORC2-<i>c</i>-Maf-controlled mitochondrial fission pathway.

Project description: Not available

| S-EPMC10182300 | biostudies-literature

VgrG Spike Dictates PAAR Requirement for the Assembly of the Type VI Secretion System.

Project description: Not available

| S-EPMC9945574 | biostudies-literature