Immune landscape in ER+ breast cancer subtypes identifies a differential role for macrophages

ABSTRACT: Current immunotherapies are ineffective for estrogen receptor positive (ER+) breast cancers, which account for nearly 70% of all breast cancers. Amongst the ER+ breast cancers, the major subtypes are invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). We utilized droplet-based single-cell RNAseq (10X Genomics) to analyzed the immune landscape of both peripheral blood and tumor infiltrating immune populations in both IDC and ILC. These analyses demonstrated substantial heterogeneity of macrophage within the tumor microenvironment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193911 | GEO | 2023/01/29

REPOSITORIES: GEO