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Effect of enhanced early life nutrition on testes miRNA transcriptome in bull calves

ABSTRACT: The aim of this study was to measure the impact of contrasting feeding regimes in the first 12 wk of life, known to impact age at puberty on the molecular control of the testes in bull calves. Holstein bull calves were designated to high (HI; n=15) or moderate (MOD; n=15) dietary groups, with diets designed to provoke growth rates of 1.0 and 0.5 kg/day, respectively. At 12 wk of age, all calves were euthanized, and testes parenchyma harvested. RNA was extracted from the testes and used for miRNAseq. Bioinformatic analysis identified 7 miRNA as differentially expressed between the HI and MOD treatment groups, with target mRNA genes invovled in pathways related to AMPK and IGF-1 signaling.

ORGANISM(S): Bos taurus

PROVIDER: GSE194041 | GEO | 2022/08/26

REPOSITORIES: GEO

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