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Secondary influenza challenge triggers lung resident memory B cell mobilization and rapid relocation for antibody secretion at infected loci

ABSTRACT: Resident memory B (BRM) cells develop and persist in the lungs of influenza infected mice and humans but their contribution to recall responses following rechallenge has not been defined. We used scRNA-seq to identify early changes in lung immune cell composition and gene expression following secondary influenza infection and tested the effect of alveolar macrophage depletion (using intranasally delivered CLL). We found an alveolar macrophage dependent upregulation of IFNG-associated pathways after influenza rechallenge, that included increased expression of CXCL9, CXCL10 and CCL5 in myeloid cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE194058 | GEO | 2022/03/28

REPOSITORIES: GEO

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Tet2 deletion in CD4+ T cells disrupts Th1 lineage commitment in memory cells and enhances T follicular helper cell recall responses

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