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Transforming Growth Factor-β (TGFβ) Prevents Hypertensive Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT Aorta)

ABSTRACT: We report bulk RNA-seq data of murine aortas at 1 week after conditional disruption of TGFβ signaling in SMCs versus controls

ORGANISM(S): Mus musculus

PROVIDER: GSE194081 | GEO | 2025/07/01

REPOSITORIES: GEO

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Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT SMC)

Project description:We report bulk RNA-seq data of Myh11 lineage marked smooth muscle cells (SMCs) from murine aortas at 1 week after conditional disruption of TGFβ signaling versus controls

2025-07-01 | GSE194082 | GEO

Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (Single cells KO vs. WT SMC)

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Transforming Growth Factor-β (TGFβ) Prevents Hypertensive Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT Aorta)

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Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (single cells WT Aorta)

Project description:We report single-cell RNA-seq data of murine aorta cells at 12 weeks of age

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Transforming growth factor beta signaling in hypertensive remodeling of porcine aorta

Project description:A porcine aortic coarctation model was used to examine regulation of gene expression in early hypertensive vascular remodeling. Aortic segments were collected proximal (high pressure) and distal (low pressure) to the coarctation after 2 weeks of sustained hypertension (mean arterial pressure>150mmHg). Porcine 10K oligoarrays used for gene expression profiling of the two regions of aorta revealed downregulation of cytoskeletal and upregulation of extracellular region genes relative to the whole genome. A genomic database search for transforming growth factor-β (TGFβ) control elements (TCE) showed that 19% of the genes that changed expression due to hypertension contained putative TCEs. Real time PCR and microarray analysis showed no change in expression of TGFβ1, TGFβ2, TGFβ3, or bone morphogenetc proteins (BMP)2 and 4, yet immunohistochemical staining for phosphorylated SMAD2, an indicator of TGFβ signaling, and for phosphorylated SMAD1/5/8, an indicator of signaling through the BMPs, showed the highest percentage of positively stained cells in the proximal aortic segments of occluded animals. For TGFβ signaling, this increase was significantly different from sham-operated controls. Western blot analysis showed no difference in total TGFβ1 protein levels with respect to treatment or aortic segment. Immunohistochemistry showed that the protein levels of latency associated peptide, was decreased in proximal segments of occluded animals. Collectively, these results suggest that activation of TGFβ, but not altered expression, may be a major mechanism regulating early hypertensive vascular remodeling.

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Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption [scRNA-seq-of-Wnt1-Cre2-mTmG]

Project description:We report single-cell RNA-seq data of Wnt1-Cre2 lineage marked, integrin alpha 8 labeled smooth muscle cells (SMCs) from murine aortas at 12 weeks of age

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Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption [scRNA-seq-of-Nkx2-5-Cre-mTmG]

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Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-27 | GSE194085 | GEO

Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (single cells WT Aorta)

Project description:Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production (single cells WT Aorta)

| PRJNA799018 | ENA

Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production

Project description:Transforming Growth Factor-β (TGFβ) Prevents Hypertension-Induced Aortic Dissection in Adult Mice via Extracellular Matrix Production

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