Epigenetic Memory of AM in vivo and ex vivo

ABSTRACT: Here we show that alveolar macrophage (AM) identity were conserved through culture expansion as determined by the analysis of epigenetic chromatin accessibility of core AM specific transcription markers and surface markers. Further, the adaptations to the culture environment were transient, reversible and fully restored to the in vivo status upon transplantation into the alveolar niche.

ORGANISM(S): Mus musculus

PROVIDER: GSE194143 | GEO | 2022/01/23

REPOSITORIES: GEO