The molecular basis of specific functions of Brachyury and Eomes for mesoderm and endoderm lineage specification

ABSTRACT: The Tbx factors Eomesodermin (Eomes) and Brachyury instruct endoderm and mesoderm specification. Both Tbx factors have common large overlap in chromatin binding sites, however their embryonic phenotypes of mutants largely differ. In this study, we delineate the distinct binding patterns and gene target sets of Eomes and Brachyury providing a molecular model of distinct fate specification programs.

ORGANISM(S): Mus musculus

PROVIDER: GSE194192 | GEO | 2023/07/26

REPOSITORIES: GEO