Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ectopic expression data of bacterial effects on NNE and NPC cells

ABSTRACT: Compared with nasopharyngeal carcinoma cell line C666-1, we found that pro-inflammatory cytokines in NP69 cells were significantly upregulated after PGN treatment We used microarray technology to identify genes that were significantly different after PGN treatment of NP69 cell lines

ORGANISM(S): Homo sapiens

PROVIDER: GSE194333 | GEO | 2022/01/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Nasopharyngeal carcinoma cell lines (expression analysis)

Project description:Three nasopharyngeal carcinoma cell lines (CNE1, CNE2, and HONE1) expression patterns against an immortalized nasopharyngeal epithelial cell line NP69.

2009-03-05 | GSE15047 | GEO

Nasopharyngeal carcinoma cell lines (expression analysis)

Project description:Three nasopharyngeal carcinoma cell lines (CNE1, CNE2, and HONE1) expression patterns against an immortalized nasopharyngeal epithelial cell line NP69. This study was done to screen genes consensually overexpressed in NPC. NP69 was used as normal control. The microarray analyses were done in a same batch.

2009-03-05 | E-GEOD-15047 | biostudies-arrayexpress

microRNA profiles of exosomes from two nasopharyngeal carcinoma cell line and nasopharyngeal epithelial cells

Project description:microRNA profiles of exosomes :Exosomes from two nasopharyngeal carcinoma cell line TW03M-oM-<M-^HEBV+M-oM-<M-^Iand TW03M-oM-<M-^HEBV-M-oM-<M-^I and Exosomes from nasopharyngeal epithelial cells NP69 Two-condition experiment, Exosomes from two nasopharyngeal carcinoma cell line vs.one normal epithelium cell line. Biological replicates:1 Exosomes from nasopharyngeal carcinoma cell line TW03M-oM-<M-^HEBV+M-oM-<M-^I, 1 Exosomes from nasopharyngeal carcinoma cell line TW03M-oM-<M-^HEBV-M-oM-<M-^I,1 Exosomes from nasopharyngeal epithelial cells NP69.

2014-05-07 | E-GEOD-57367 | biostudies-arrayexpress

microRNA profiles of exosomes from two nasopharyngeal carcinoma cell line and nasopharyngeal epithelial cells

Project description:microRNA profiles of exosomes :Exosomes from two nasopharyngeal carcinoma cell line TW03（EBV+）and TW03（EBV-） and Exosomes from nasopharyngeal epithelial cells NP69

2014-05-07 | GSE57367 | GEO

Effect of BAY2402234 treatment on gene expression in nasopharyngeal carcinoma C666-1 cells

Project description:The DHODH inhibitor BAY2402234 has shown promising anti-tumor effects in various cancer types, but its molecular mechanisms in nasopharyngeal carcinoma remain unclear. This study investigates the transcriptomic changes induced by BAY2402234 in C666-1 nasopharyngeal carcinoma cells. We performed RNA-seq analysis of C666-1 cells treated with 2nM BAY2402234 for 48 hours compared to untreated control cells. Differential gene expression analysis revealed significant alterations in multiple pathways, including p53 signaling, cell cycle regulation, apoptosis, and ribosome biogenesis. Our findings provide insights into the molecular mechanisms underlying BAY2402234's anti-tumor effects in nasopharyngeal carcinoma, highlighting its potential as a therapeutic agent through modulation of critical cellular pathways involved in cancer progression.

2025-04-02 | GSE293574 | GEO

Nasopharyngeal carcinoma cell lines (copy number analysis)

Project description:Five NPC cell lines (HONE1, CNE1, CNE2, 5-8F, and 6-10B) and an immortalized nasopharyngeal epithelial cell line NP69 were evaluated with 250K SNP arrays (Affymetrix) to detect the genome-wide DNA copy number alterations.

2009-03-05 | GSE15051 | GEO

Expression data from ectopic expression of BDH2 in Nasopharyngeal carcinoma (NPC) cell lines

Project description:Compare with normal nasopharyngeal epithelial cells, we found BDH2 was decreased in NPC cells, we found that BDH2 inhibited proliferation, colony formation, migration and invasion in NPC cells. We used microarrays to identify differential genes regulated by BDH2 in NPC cell lines.

2018-09-08 | GSE119642 | GEO

Expression data from ectopic expression of ACAT1 in Nasopharyngeal carcinoma (NPC) cell lines

Project description:Compare with normal nasopharyngeal epithelial cells, we found ACAT1 was decreased in NPC cells, we found that ACAT1 inhibited proliferation, colony formation, migration and invasion in NPC cells. We used microarrays to identify differential genes regulated by ACAT1 in NPC cell lines. We used microarrays to identify differential genes regulated by ACAT1 in NPC cell lines.

2020-07-28 | GSE155206 | GEO

Transcription profiling by array of human nasopharyngeal carcinoma cells over-expressing DOC2/hDAB2

Project description:To search for potential genes and pathways regulated by DOC2-hDAB2 in nasopharyngeal carcinoma, we compared the expression profile of C666-1 cells overexpressing DOC2/hDAB2 to vector control-transfected cells.

2010-04-22 | E-MEXP-2677 | biostudies-arrayexpress

Bioinformatic Analysis of mRNA and miRNA Expression Patterns In p53 Knock-out C666-1 cells [mRNA]

Project description:Unlike other EBV-associated human tumors, nearly 100% wild-type p53 gene is found in NPC, p53 protein is also frequently found to accumulate in NPC biopsies. However, the role of p53 in EBV-positive nasopharyngeal carcinoma is unclear. The expression profiles of mRNAs and miRNAs of EBV-positive NPC cells are unknown. To elucidate the function of p53 in EBV-positive NPC, we used the CRISPR-Cas9 gene editing system to p53 knockout C666-1 cells with Epstein-Barr virus and performed mRNA and miRNA sequencing in p53 KO C666-1 and their control cells. Gene Ontology (GO), KEGG and STRING analyses were implemented to identify significant functions, pathways of differentially expressed mRNAs. Through comparative analysis of p53-regulated genes from EBV-positive C666-1 cells and EBV-negative HONE2 cells with p53 target genes from 16 high throughput data sets, we found that the number of target genes and KEGG pathways downregulated by p53 in EBV-positive C666-1 cells were much less than in EBV-negative HONE2 cells, but “p53 signaling pathway” and related cell cycle arrest and apoptosis genes were significantly downregulated after knockout of p53 gene in C666-1 cells. To explore the effect of p53 on cell cycle and apoptosis, we established stable p53 C666-1-KO cell lines with stable expression of exogenous p53-WT and their control cell lines. Using the established cell lines, we observed that stable expression of p53 repressed cell proliferation, increased cell apoptosis and blocked G1/S phase progression. In conclusion, our results show that the accumulated p53 protein in EBV-positive C666-1 cells still has some tumour suppressor functions such as blocking cell-cycle progression and promoting apoptosis, but the ability of p53 to downregulate gene expression is inhibited.

2021-03-01 | GSE138258 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data