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Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

ABSTRACT: We revealed that the MPLSST neurons are excitatory neurons releasing neurotransmitter glutamate,and reveal that more than half of these neurons corelease neuropeptides SST and PTH2

ORGANISM(S): Mus musculus

PROVIDER: GSE194338 | GEO | 2022/01/28

REPOSITORIES: GEO

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Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

Project description:Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

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PatchSeq experiment on somatostatin-expressing (Sst) neurons from mouse ventral tegmental area (VTA). Full-length single cell sequencing.

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Sp9 regulates medial ganglionic eminence-derived cortical interneuron development

Project description:In the mammalian cortex, about 60% of GABAergic interneurons, mainly including parvalbumin-expressing (PV+) and somatostatin (SST+) interneurons are generated from the medial ganglionic eminence (MGE) in the subpallium and tangentially migrate to the cortex. Here we analyze the role of the Sp9 transcription factor in regulating the development of MGE-derived cortical interneurons. We show that SP9 is widely expressed in the MGE subventricular zone (SVZ) and in MGE-derived migrating interneurons. By analyzing Sp9 null and conditional mutant mice, we demonstrate that Sp9 promotes MGE progenitor proliferation in the SVZ and is required for the normal patterning of tangential migration and the laminar distribution of MGE-derived cortical GABAergic interneurons. Loss of Sp9 function results in a ~50% reduction of MGE-derived cortical interneurons, an ectopic aggregation of MGE-derived neurons in the embryonic ventral telencephalon, and an increased ratio of SST+/PV+ cortical interneurons. Finally, we provide evidence that Sp9 regulates MGE derived cortical interneuron development through promoting expression of the Lhx6 and Lhx8 transcription factors.

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