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Genome-wide mapping of Fos binding site (K562)

ABSTRACT: Proto-oncogene c-Fos is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Fos dimerizes with another transcription factor Jun to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf

ORGANISM(S): Homo sapiens

PROVIDER: GSE19546 | GEO | 2009/12/31

REPOSITORIES: GEO

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Genome-wide mapping of Fos binding site (K562)

Project description:Proto-oncogene c-Fos is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Fos dimerizes with another transcription factor Jun to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Map binding sites of transcription factor Fos in the genome of K562 cells. The K562 input data has been deposited in GEO as GSM325934.

2009-12-31 | E-GEOD-19546 | biostudies-arrayexpress

Genome-wide mapping of Jun binding site (K562)

Project description:Proto-oncogene c-jun is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Jun dimerizes with another transcription factor Fos to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf

2009-12-31 | GSE19545 | GEO

Genome-wide mapping of Jun binding site (K562)

2009-12-31 | E-GEOD-19545 | biostudies-arrayexpress

Intricate coupling between the transactivation and basic-leucine zipper domains governs the CK2-dependent phosphorylation of ATF4

Project description:Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of co-activators and co-repressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these mechanisms, the structural and functional basis of transactivation domain in yet poorly understood. Here, we focused on ATF4/CREB-2, an essential transcription factor for cellular stress adaptation. We found that the N-terminal region of the transactivation domain is involved in transient long-range interactions with the basic-leucine zipper domain. In vitro phosphorylation assays with the protein kinase CK2 show that the presence of the basic-leucine zipper domain is required for optimal phosphorylation of the transactivation domain. This study uncovers the intricate coupling existing between the transactivation and basic-leucine zipper domains of ATF4 and highlights its potential functional relevance.

2023-03-11 | PXD029704 | Pride

Fos

Project description:Rattus norvegicus Fos, Fos proto-oncogene, AP-1 transcription factor subunit [Source:RGD Symbol;Acc:2626], is expressed in 5 baseline experiment(s);

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FOS

Project description:Monodelphis domestica FOS, Fos proto-oncogene, AP-1 transcription factor subunit [Source:NCBI gene;Acc:100018285], is expressed in 2 baseline experiment(s);

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Fos

Project description:Rattus norvegicus Fos, Fos proto-oncogene, AP-1 transcription factor subunit [Source:RGD Symbol;Acc:2626], is differentially expressed in 6 experiment(s);

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FOS

Project description:Anolis carolinensis FOS, Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796], is expressed in 1 baseline experiment(s);

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FOS

Project description:Macaca mulatta FOS, Fos proto-onco, AP-1 transcription factor subunit [Source:VGNC Symbol;Acc:VGNC:84340], is expressed in 3 baseline experiment(s);

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FOS

Project description:Oryctolagus cuniculus FOS, Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796], is expressed in 1 baseline experiment(s);

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