RNA-sequencing of iPSC-derived blood-brain barrier cell types across microenvironments

ABSTRACT: The blood-brain barrier (BBB) is lined by brain microvascular endothelial cells (BMECs) which regulate transport into and out of the brain. We used human induced pluripotent stem cell (iPSC)-derived cell types to model BBB function within 2D and 3D in vitro models. We compare gene expression between different iPSC-derived cell types, and specifically profile the response of iPSC-derived BMEC-like cells (iBMECs) to differentiation media volume, microenvironmental cues, and cytokines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195519 | GEO | 2022/01/30

REPOSITORIES: GEO