Acetylation-specific interference by anti histone H3K9ac intrabody results in precise modulation of gene expression

ABSTRACT: The goal of this study is to compared the global gene expression changes driven by the histone PTM-selective interference with those induced by the inhibition of the corresponding modifying enzymes. We chose site-specific histone H3 acetylation as a target for this comparison, and we investigated the transcriptomic response in yeast cells, either expressing the intrabody anti-H3K9ac scFv-58F or treated with HATs inhibitors (Curcumin and CPTH2)

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE195547 | GEO | 2022/01/30

REPOSITORIES: GEO