Transcriptomics

Dataset Information

26

Transcriptional program of terminal granulocytic differentation


ABSTRACT: To characterize the transcriptional program that governs terminal granulocytic differentation in vivo, we performed comprehensive microarray analysis of human bone marrow population highly enriched for promyelocytes, myelocytes / metamyelocytes and neotrophils. Overall design: Bone marrow and peripheral blood samples were collected from healthy individuals in parallel. Cell populations representing successive stages of terminal granulocytic differentation were isolated from human bone marrow samples by 2-layer density gradient centrifugation, neutrophils were collected from peripheral blood using 1-layer density gradient centrifugation. All populations were depleted of nongranulocytic cells by immunomagnetic sorting.

REANALYSED by: GSE86363

INSTRUMENT(S): [HG-U133A] Affymetrix Human Genome U133A Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Troels Torben Marstrand  

PROVIDER: GSE19556 | GEO | 2009-12-19

SECONDARY ACCESSION(S): PRJNA122397

REPOSITORIES: GEO

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