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SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human primary endometrial decidualization

ABSTRACT: To detect the direct target genes of SOX4 in differentiated human primary endometrial stromal cells, differentiated human primary endometrial stromal cells cells at the presence of MPA, E2 and cAMP are collected and subjected to ChIP-Seq. After aligned to human Hg38 by STAR, peaks are called by MACS2. Our results show that SOX4 is the key regulator for decidualization by regulating FOXO1, STAT3, PRL and FOSL2. This specific enrichment is confirmed by ChIP-qPCR. Additionally, there are also some other direct genes of SOX4, indicating the essential role of SOX4 in decidualization. This ChIP-Seq data provides fundamental information for our further physiological study of SOX4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195606 | GEO | 2022/01/28

REPOSITORIES: GEO

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SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

Project description:To detect the direct target genes of SOX4 in differentiated human endometrial stromal cells(hEnSC), differentiated hEnSC cells at the presence of MPA, E2 and cAMP are collected and subjected to ChIP-Seq. After aligned to human Hg38 by STAR, peaks are called by MACS2. Our results show that SOX4 is the key regulator for decidualization by regulating FOXO1, STAT3, PRL and FOSL2. This specific enrichment is confirmed by ChIP-qPCR. Additionally, there are also some other direct genes of SOX4, indicating the essential role of SOX4 in decidualization. This ChIP-Seq data provides fundamental information for our further physiological study of SOX4.

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SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human primary endometrial decidualization

Project description:SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human primary endometrial decidualization

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