Single Nuclei Transcriptomics Delineates Complex Interactions Between Immune and Renal Cells Contributing to Kidney Graft Fibrosis

ABSTRACT: Purpose: Chronic allograft dysfunction (CAD) remains a major obstacle in kidney transplantation. However, the molecular pathogenesis of human CAD is unknown. Herein, we tested the hypothesis that single nuclei transcriptomics of human kidney allograft fibrosis will reveal diverse cell types, deconvolve complex fibrosis-driving pathways, and provide deeper insights into the progression of kidney allograft dysfunction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE195718 | GEO | 2023/03/06

REPOSITORIES: GEO