OPTN as a therapeutic target for acetaminophen-induced liver injury by activating mitophagy

ABSTRACT: Acetaminophen (APAP) is a leading cause of acute liver failure in Western countries result from the accumulation of damaged mitochondria. However, there is no related clinically useful therapeutic intervention. Optineurin (OPTN) is a multifunctional protein involved in autophagy, oxidative stress, as well as nuclear factor κB (NF-κB) and IRF3 signaling, and OPTN mutations are associated with several human diseases.Here, to study the role of OPTN in APAP induced liver injury, we performed RNA-seq analysis of isolated control and Optn-/- mouse liver tissues.

ORGANISM(S): Mus musculus

PROVIDER: GSE195753 | GEO | 2024/08/21

REPOSITORIES: GEO