Establish the mechanism of the effect of panobinostat on murine Pax2+ renal progenitors.

ABSTRACT: We generated single-cell RNA sequencing (scRNAseq) datasets of primary cultures of mouse Pax2+ renal progenitors isolated from healthy mice and treated in vitro with vehicle or the HDAC inhibitor panobinostat. Pax2+ cells expressed progenitor cells markers in absence of tubular and endothelial cell markers and following treatment with panobinostat, upregulated the expression of podocyte-specific markers.

ORGANISM(S): Mus musculus

PROVIDER: GSE195785 | GEO | 2022/09/23

REPOSITORIES: GEO