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The NFIB/CARM1 Axis is a Therapeutic Target for Small Cell Lung Cancer

ABSTRACT: We identified NFIB as a CARM1 substrate and showed that this transcription factor utilizes CARM1 as a coactivator. Importantly, NFIB harbors both oncogenic and metastatic activities, and is often overexpressed in small cell lung cancer (SCLC). Using a SCLC mouse model, we show that both CARM1 and the CARM1 methylation site on NFIB are critical for the rapid onset of SCLC. By performing the high-throughput sequecing analysis, we found that CARM1-null and NFIB-R388K mutant mouse SCLC tumors share the ability to regulate chromatin accessbility and have similar gene expression pattern.

ORGANISM(S): Mus musculus

PROVIDER: GSE195843 | GEO | 2022/02/07

REPOSITORIES: GEO

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The NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer

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