Understanding the molecular basis of pheneotypic heteroegenity in mouse model of triple negative breast cancer (TNBC) using RNA sequencing

ABSTRACT: We injected GFP tagged mouse metastatic breast cancer cell line, 4T1 (4T1GFP) into the mammary fat-pad of BALB/c mice. From 4T1GFP primary tumor, we obtained two distinct tumor cell subpopulations that differed in terms of their in vitro and in vivo phenotypes with one subpopulation being more aggresive compared to the other. We performed transcriptomic analysis using RNA sequencing to identify the molecular mediators of this intratumoral phenotypic heterogeneity.

ORGANISM(S): Mus musculus

PROVIDER: GSE195995 | GEO | 2023/10/23

REPOSITORIES: GEO