Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A lysosomal surveillance response to stress extends healthspan

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE196023 | GEO | 2023/02/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A lysosomal surveillance response to stress extends healthspan [Exp3]

Project description:Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homeostasis and health. However, how lysosomal activity can be boosted to counteract aging and aging-related diseases remains elusive. Here, we reveal that silencing specific vacuolar H+-ATPase subunits (e.g. vha-6), that are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive transcriptional response typified by induction of a set of transcripts involved in lysosomal function and proteolysis, which we termed the lysosomal surveillance response (LySR). LySR activation is characterized by boosted lysosomal activity, enhanced clearance of protein aggregates in worm models of Alzheimer's disease, Huntington’s disease and amyotrophic lateral sclerosis, thereby improving fitness. The GATA transcription factor ELT-2 governs the LySR program and its associated beneficial effects. Activating the LySR pathway may therefore represent an attractive mechanism to reduce proteotoxicity and, as such, potentially extend healthspan.

2025-05-03 | GSE296199 | GEO

A lysosomal surveillance response to stress extends healthspan [Exp2]

2023-02-03 | GSE196022 | GEO

A lysosomal surveillance response to stress extends healthspan [Exp1]

2023-02-03 | GSE196021 | GEO

A lysosomal surveillance response to stress extends healthspan

Project description:A lysosomal surveillance response to stress extends healthspan

| PRJNA803026 | ENA

A lysosomal surveillance response to stress extends healthspan [Exp3]

Project description:A lysosomal surveillance response to stress extends healthspan [Exp3]

| PRJNA1258196 | ENA

A lysosomal surveillance response to stress extends healthspan [Exp1]

Project description:A lysosomal surveillance response to stress extends healthspan [Exp1]

| PRJNA803027 | ENA

A lysosomal surveillance response to stress extends healthspan [Exp2]

Project description:A lysosomal surveillance response to stress extends healthspan [Exp2]

| PRJNA803034 | ENA

mitoCPR - a surveillance pathway that protects mitochondria in response to mitochondrial import stress

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-03-16 | GSE96728 | GEO

Lost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-28 | E-GEOD-48420 | biostudies-arrayexpress

A Surveillance System of Active Enhancers by a RACK7-histone Demethylase Complex

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-07 | E-GEOD-71327 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data