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RNA profiling in lungs of WT, IFN-g-/- and IL-4-/- mice before and after Mycoplasma pulmonis infection

ABSTRACT: Full title: Mouse Inflammatory Cytokines and Receptors Microarray-RNA profiling in lungs of WT, IFN-g-/- and IL-4-/- mice before and after Mycoplasma pulmonis infection RNA profiling of inflammatory chemokines, cytokines and receptors in lungs of 4-6 week old wild-type, IFN-g-/- and IL-4-/- BALB/cJ mice before and after 14-day Mycoplasma pulmonis infection

ORGANISM(S): Mus musculus

PROVIDER: GSE19623 | GEO | 2010/01/01

SECONDARY ACCESSION(S): PRJNA122577

REPOSITORIES: GEO

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RNA profiling in lungs of WT, IFN-g-/- and IL-4-/- mice before and after Mycoplasma pulmonis infection

Project description:Full title: Mouse Inflammatory Cytokines and Receptors Microarray-RNA profiling in lungs of WT, IFN-g-/- and IL-4-/- mice before and after Mycoplasma pulmonis infection RNA profiling of inflammatory chemokines, cytokines and receptors in lungs of 4-6 week old wild-type, IFN-g-/- and IL-4-/- BALB/cJ mice before and after 14-day Mycoplasma pulmonis infection RNA pooled from lungs of each group- Uninfected and Infected; Experiment performed twice. With 3 mice in each of the uninfected and infected groups in the first experiment and 4 mice in each group in the second experiment; comparison Mycoplasma infected vs. uninfected mice within each strain of mice

2010-05-16 | E-GEOD-19623 | biostudies-arrayexpress

Mouse Inflammatory Cytokines and Receptors Microarray-RNA profiling in F4/80+ and CD11c+ cells from lungs of WT mice before and after Mycoplasma pulmonis infection

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Mouse Inflammatory Cytokines and Receptors Microarray-RNA profiling in F4/80+ and CD11c+ cells from lungs of WT mice before and after Mycoplasma pulmonis infection

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Mus musculus

Project description:Mouse Inflammatory Cytokines and Receptors Microarray-RNA profiling in F4/80+ and CD11c+ cells from lungs of WT mice before and after Mycoplasma pulmonis infection

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Mus musculus

Project description:RNA profiling in lungs of WT, IFN-g-/- and IL-4-/- mice before and after Mycoplasma pulmonis infection

| PRJNA122577 | ENA

The global transcriptome of whole lungs extracted from M. tuberculosis infected C57BL6 mice

Project description:The study aims at understanding the global nature of the immune responses within the the lung tissue 28 days post infection with Mycobacterium tuberculosis. Comparing the whole transcriptome of infected lungs to that of an uninfected lungs revealed a plethora of immune mechanisms driven by various cytokines. IFN-γ, IL-6, IL-2, TNFα were the major cytokines observed. We observed significant differential expression of gene involved in the JAK-STAT and the MAPK signalling pathways. We observed an interplay of the immune regulatory genes and various non-immune genes controlling the metabolism, apoptosis, cell growth, post translational modifications etc.

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Real-time quantitative PCR analysis of mouse lungs

Project description:Balb/cJ mouse received control RNAi or RNAi to 8-oxoguanine DNA glycosylase (Ogg1) intranasally prior to the exposure for 1 h to a) glucose oxidase (1 mU) to induce OGG1-BER or b) OGG1-BER product 8-oxoguanine (1 M-NM-<M). We used SABiosciences Mouse Inflammatory Cytokines & Receptors PCR Array (PAMM-011A) to quantitate inflammatory gene expression dependent on OGG1 and its product 8-oxoguanine. After intranasal challenge with glucose oxidase or 8-oxoguanine, mice were sacrificed and lungs were collected and processed to obtain RNA. Total pooled (n=5) RNA (1 M-NM-<g) was reverse transcribed into cDNA using SuperscriptM-BM-. III First Strand Synthesis System (Invitrogen), mixed with equal amounts of 2X SYBR Green Supermix (Qiagen) and 20 M-NM-<l of reaction mixture was added to each well of the PAM-011A array. The reaction was evaluated using an ABI PRISMM-BM-. 7000 Sequence Detection System using recommended settings by SABiosciences.

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