Transcriptomics

Dataset Information

0

Genome wide transcriptional change by GPR155/LYCHOS loss


ABSTRACT: Cholesterol, a key building block for cellular membranes and a precursor for steroid hormones, was recently identified as a major nutrient input that activates the master growth regulator, mammalian Target of Rapamycin Complex 1 (mTORC1) kinase. Here we identify a novel lysosomal tranmembrane protein , which we name LYsosomal CHOlesterol Signaling (LYCHOS, previously annotated as GPR155/DEPDC3), as an essential factor that enables cholesterol-dependent activation of mTORC1. RNAseq analysis of LYCHOS-depleted cells showed a pronounced dowregulation of metabolic genes involved in glycolysis, pentose phosphate pathway and lipid biosynthesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196384 | GEO | 2022/09/01

REPOSITORIES: GEO

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