Integrated transcriptomic and in silico drug screening identifies potential stroma-targeting therapeutics in pancreatic cancer

ABSTRACT: This study identifies a gene panel that can distinguish two stromal subgroups of resected pancreatic cancers which have different microenvironment features and prognosis, and can be targeted by different therapeutic approaches. In-silico and in-vitro analysis indicates that our proposed signature could be further investigated as a predictor of response of immunomodulatory agents, including anti CD40 therapeutics

ORGANISM(S): Homo sapiens

PROVIDER: GSE196524 | GEO | 2025/02/10

REPOSITORIES: GEO