Human malignant mesothelioma NCI-H226 cells treated with TEAD inhibitor K-975 in SCID mice.

ABSTRACT: We investigate the dependence of human malignant mesothelioma on functional TEAD transcription factors to maintain fully established tumors in vivo. We show that TEAD inhibitor K-975 stops tumor growth in vivo, eventually causing tumor regression, by downregulating TEAD activity and altering, thus, TEAD-dependent transcription in a dysfunctional Hippo genetic background. Our data  validate the concept of inhibiting an activated YAP1/TEAD complex for the treatment of malignant pleural mesothelioma patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196726 | GEO | 2022/02/17

REPOSITORIES: GEO